Resumen:
A two-variable stochastic model for diffusion-limited nucleation is developed using a formalism derived from fluctuating hydrodynamics. The model is a direct generalization of the standard classical nucleation theory (CNT). The nucleation rate and pathway are calculated in the weak-noise approximation and are shown to be in good agreement with direct numerical simulations for the weak-solution/strong-solution transition in globular proteins. We find that CNT underestimates the time needed for the formation of a critical cluster by two orders of magnitude and that this discrepancy is due to the more complex dynamics of the two variable model and not, as often is assumed, a result of errors in the estimation of the free energy barrier.
Palabras Clave: nucleation, classical nucleation theory, proteins, Fokker–Planck equation
Índice de impacto JCR y cuartil WoS: 2,209 - Q2 (2015); 2,700 - Q3 (2022)
Referencia DOI:
https://doi.org/10.1088/0953-8984/27/23/235101
Publicado en papel: Junio 2015.
Publicado on-line: Mayo 2015.
Cita:
J.F. Lutsko, M.A. Durán-Olivencia, A two-parameter extension of classical nucleation theory. Journal of Physics: Condensed Matter. Vol. 27, nº. 23, pp. 235101-1 - 235101-18, Junio 2015. [Online: Mayo 2015]
